Job Title:
Early Career Researcher in Pluripotent Stem Cells
The Dr. Aranguren laboratory at the Center for Applied Medical Research (CIMA) - University of Navarra seeks a highly motivated and talented researcher to contribute to an exciting project on pluripotent stem cells.
Our research focuses on overcoming key challenges hindering the generation of humanized organs in pigs through blastocyst complementation. We aim to understand interspecies barriers and develop innovative methods for producing transplantable organs in pigs.
Organ transplantation is a life-saving treatment for end-stage organ failure, but the number of available donor organs is insufficient. Generation of humanized organs from induced pluripotent stem cells (iPSCs) in animal recipients by blastocyst complementation could solve this bottleneck and provide a continuous source of organs for clinical use.
Key Objectives:
* Develop strategies to increase human iPSC chimeric potential
* Generate interspecific chimeras
We have established a technology for generating xeno-organs using mouse models and have studied the heterogeneity of naïve hiPSC culture. Our team has experience with CRISPR/Cas9 gene editing techniques, basic molecular biology, and embryo histology.
The successful candidate will join our team in addressing fundamental processes in interspecies organogenesis and contributing to the development of innovative methods for producing transplantable organs.
Requirements:
* Master's degree in Biological Sciences
* Background in molecular and cellular biology
* Excellent written and oral communication skills
* Ability to work independently and collaboratively
Interested candidates should submit a cover letter and CV through the application or to Dr. Xabier Aranguren. Reference letters are appreciated.