Innovative Medicine, Translational Pharmacokinetics, Pharmacodynamics & Investigative Toxicology Senior Scientific Director PSTS
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. For more than 130 years, diversity, equity & inclusion (DEI) has been a part of our cultural fabric at Johnson & Johnson and woven into how we do business every day. Our diverse workforce and culture of belonging accelerate innovation to solve the world's most pressing healthcare challenges.
Position Summary
As Senior Scientific Director PSTS, you will provide scientific/strategic guidance and leadership to a team of highly motivated and passionate translational scientists (~25) with expertise in biochemical, cellular and molecular pharmacology/toxicology and safety pharmacology. The Senior Scientific Director PSTS will guide the strategic direction and execution of preclinical safety science efforts to inform the selection and characterization of novel targets as well as the transition of new therapies from discovery to early-stage clinical development and ultimately to approved therapies for patients. This role is responsible for establishing a robust translational safety assessment framework, bridging preclinical and clinical safety data and ensuring that clinical insights are translated back into preclinical and early discovery phases, informing and optimizing preclinical safety models and early drug discovery approaches and ultimately improving the safety profiles of future therapies.
Key Responsibilities
1. Lead and manage a global team of experts in translational and investigative safety to ensure safety assessments align with company standards and regulatory requirements.
2. Guide efforts to integrate clinical safety data back into preclinical models (reverse translation), improving predictive accuracy and addressing potential safety risks early in development.
3. Serve/Act as the primary point of contact for PSTS on the initiative of creating "a translational safety community of practice" between Global Medical Safety and PSTS.
4. Oversee the design and execution of investigative toxicology studies to understand mechanisms of toxicities, support risk assessments, and mitigate safety concerns.
5. Evaluate and embrace emerging technologies, such as AI-driven safety models, computational toxicology, and in vitro/in vivo models, for potential integration into safety workflows.
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