Organisation/Company: FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA
Department: Administration
Research Field: Biological sciences » Biology
Researcher Profile: First Stage Researcher (R1)
Positions: PhD Positions
Country: Spain
Application Deadline: 27 Nov 2024 - 23:59 (Europe/Madrid)
Type of Contract: Temporary
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description
* Synergistic combinations for cancer Immunotherapy based on agonist immunotherapy agents and interference with pro-tumoral Inflammation. SynerCombIT.
* Transformative opportunities in the field of cancer immunotherapeutics usually stem from combinations involving agents of immunotherapy among themselves or in synergistic combinations with either chemotherapy or antiangiogenics.
* However, multiple lines of evidence show that there exist inflammatory responses in cancer-bearing hosts that act to curtail the efficacy of immunotherapy.
* Such deleterious activities are orchestrated by soluble mediators and are mainly mediated by myeloid leukocytes (tumor-associated macrophages and neutrophils).
* The overarching goal of SynerCombIT is to use innovative preclinical and clinical research to test therapeutic approaches against difficult to treat mouse cancer models.
* The project will rely on genetically modified mouse strains, multiplex tissue immunofluorescence, transcriptomics, and a variety of in-vivo and ex-vivo functional immune assessments.
* The selected candidate will work in a dynamic and collaborative environment, participating in an innovative project that addresses fundamental questions in the field of immunotherapy.
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