Organisation/Company: FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA
Department: Administration
Research Field: Biological sciences » Biology
Researcher Profile: First Stage Researcher (R1)
Positions: PhD Positions
Country: Spain
Application Deadline: 27 Nov 2024 - 23:59 (Europe/Madrid)
Type of Contract: Temporary
Job Status: Full-time
Offer Description
* Synergistic combinations for cancer Immunotherapy based on agonist immunotherapy agents and interference with pro-tumoral Inflammation. SynerCombIT.
* Transformative opportunities in the field of cancer immunotherapeutics usually stem from combinations involving agents of immunotherapy among themselves or in synergistic combinations with either chemotherapy or antiangiogenics.
* However, multiple lines of evidence show that there exist inflammatory responses in cancer-bearing hosts that act to curtail the efficacy of immunotherapy.
* Such deleterious activities are orchestrated by soluble mediators and are mainly mediated by myeloid leukocytes (tumor-associated macrophages and neutrophils).
* The overarching goal of SynerCombIT is to use novel approaches in conjunction with the interference of protumoral inflammatory mediators, testing such therapeutic approaches against difficult to treat mouse cancer models.
* Our primary proinflammatory targets to be neutralized are TNFalpha, CXCR1/2 chemokines, prostaglandin-E2 or/and IL-6.
* SynerCombIT plans to interfere with neutrophil chemoattractant and NETosis in combination with other immunotherapy approaches.
* The selected candidate will work in a dynamic and collaborative environment, participating in an innovative project that addresses fundamental questions in the field of immunotherapy.
#J-18808-Ljbffr