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Mission
Tasks and Responsibilities
* In collaboration with senior/principal scientists in the team, identify, evaluate, and probe emerging methods for immune cell isolation, culture, differentiation, and activation.
* Design, execute, interpret, and optimize in vitro assays that can encompass multi-parameter flow cytometry, qRT-PCR, JESS, proliferation, and immunoassays, in order to profile hit, lead and clinical molecules.
* In collaboration with senior/principal scientist in the team, design and optimize state-of-the-art experimental protocols for gene modulation and cell line/primary cell engineering, including RNA interference, stable transfection and CRISPR-Cas9 mediated gene editing, in order to study signalling pathways of interest.
* Independently analyse experimental results, and present data analysis and plans at cross-functional meetings.
Education
* MSc with 1+ years of experience or PhD in Immunology, Molecular Biology or Cellular Biology.
Specific Knowledge
* Experience in cell culture. Experience with primary immune cells (PBMC, lymphocytes…) or with skin cells such as primary keratinocytes.
* Theoretical and experimental background in cellular assays such as flow cytometry, ELISA, HTRF, qPCR, WB. Experience with functional immunology assays (e.g. PBMC activation, MLRs) and spectral flow cytometry would be a plus.
* Experience with gene modulation assays (siRNA and plasmids transfection, lentiviral transduction of shRNA…) would be a plus.
* Interest in new therapeutic modalities such as bispecific antibodies, Targeted Protein Degradation, cell or mRNA therapies would be a plus.
* Excellent organization skills and track record for generation of high data quality.
* Track record of continual growth, curiosity, and drive to learn.
* Team player with ability to collaborate and communicate effectively across several scientific disciplines.
* Advanced English level required.
Values
* Care: we listen & empathize, we value diverse perspectives & backgrounds and we help each other succeed.
* Courage: we challenge the status quo, we take full ownership and we learn from our success & failures.
* Innovation: we put the patient and customer at the center, we create novel solutions and we empower entrepreneurial mindsets.
* Simplicity: we act decisively and avoid over-analysis, we understand why before we act and we are agile & keep things simple.
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