Offer Description
The Josep Carreras Leukaemia Research Institute (IJC) is a comprehensive cancer research center dedicated to conducting research and driving innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. It was created in 2010, and since then has experienced exponential growth.
The IJC is also part of the network of Excellence Research Centers of Catalonia (CERCA) and was accredited as a Severo Ochoa Center of Excellence by the Ministry of Science, Innovation, and Universities in 2024. Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer (FCAECC). Additionally, IJC is one of the centers integrated into the Institut de Recerca Germans Trias i Pujol (IGTP) accreditation as an Accredited Health Research Institute (IIS) by the Carlos III Health Institute (ISCIII).
We are seeking a Predoctoral Researcher for the Regulatory RNA and chromatin group led by Dr. Sònia Guil.
RESEARCH DESCRIPTION
The team of Sònia Guil at the Josep Carreras Leukaemia Research Institute is looking for a highly motivated PhD student to investigate the molecular basis of multiple myeloma.
Multiple myeloma (MM) ranks as the second most common hematological malignancy, characterized by the uncontrolled proliferation of monoclonal plasma cells within the bone marrow. The malignant progression of MM is closely linked with the accumulation of acquired genetic events and additional epigenetic alterations. Despite the availability of highly effective anti-MM agents that have enhanced long-term survival rates, disease relapse and multidrug resistance are still a challenge. Therefore, there is an urgent need to investigate distinct molecular mechanisms underlying myeloma tumorigenesis, including epigenetic mechanisms driving resistance patterns, to improve long-term patient prognosis and clinical outcomes.
Building on previous studies in the group, the project will further investigate the role of specific long noncoding RNAs at the interface with the cellular response to chemotherapy, combining mechanistic dissection of their regulatory functions with clinicopathological correlations. The research will employ techniques such as single-cell transcriptome analysis, epitranscriptomic profiling, iCLIP-seq, and CRISPRi/CRISPRa approaches, along with other molecular and biochemical methods.
The study aims to uncover the molecular interplay between treatment resistance and noncoding RNAs, laying the groundwork for the development of novel therapeutic strategies for multiple myeloma.
WHO WE ARE?
What makes us different?
The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases.
The IJC's vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results and the cure of patients affected by leukemia and other malignant hemopathies through innovation, sustainability, social responsibility, talent, and professional experience.
HR Excellence
In 2019, IJC was honored with the “Human Resources Excellence in Research Award” by the European Commission, recognizing the alignment of our human resources policies with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers. The Human Resources Strategy for Researchers (HRS4R) guides research centers of excellence in implementing and upholding these standards within their policies, emphasizing training, professional development, and mobility opportunities.
The IJC's commitment to these values and principles strengthens our internal policies and ensures that our members have the optimal conditions and environment for their professional development.
Requirements
Research Field: Medical sciences » Cancer research
Education Level: Master Degree or equivalent
Specific Requirements
We are seeking a highly-motivated scientist with a Master's degree and prior laboratory experience to contribute to research in epigenetic regulation in cancer, noncoding RNA biology, and multi-omics data integration. The successful candidate will play a role in advancing RNA-based therapeutic approaches in multiple myeloma. Candidates should have a creative mindset and a strong biomedical background, with experience in functional molecular and/or biochemical assays.
General skills required
1. Master's degree or equivalent in genomics, molecular biology, or epigenetics.
2. Acceptance and enrollment in a Doctoral program related to the research area.
3. High motivation and enthusiasm for biomedical research.
4. Previous experience in RNA biology or a related research area.
5. Strong collaborative and communication skills.
6. Proficiency in English (spoken and written) is required; knowledge of Catalan is a plus.
Technical skills required
1. Experience with basic cellular and molecular biology techniques.
2. Familiarity with statistical analysis is desirable.
WHAT WE OFFER
1. A dynamic, collaborative, and international research environment with access to cutting-edge technologies.
2. Opportunity to work alongside experts in medicine, genomics, and bioinformatics.
3. Full-time, 1-year temporary contract with potential for renewal.
4. Involvement in an exciting and innovative research project.
5. Contract funded by the CELLEX Private Foundation.
6. A stimulating work environment in the Barcelona metropolitan area.
7. Integration into a multinational and highly collaborative lab.
DEADLINE FOR APPLICATIONS
Please submit your application by 25/02/2025. #J-18808-Ljbffr